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Difference between In the loose and On the loose

in the loose(of things) not packed or tied up:

  • Auctioneers thread their way through the lanes of tobacco “in the loose” on the warehouse floors.

on the loose

1. running around free after an escape from prison, captivity, etc.:

  • Look out! There is a bear on the loose from the zoo.

2. free from the restraints of morality or discipline:

  • Most kids enjoy being on the loose when they go to college.