let go of something—stop holding smth.; release smth.:
- As soon as I let go of the leash, the dog ran away.
let go with something—give vent to laughter, angry words, etc.:
- The lawyer let go with a vicious attack on the tactics of his opponent.
Note: Neither expression correlates in meaning with the phrase let something go—pay no attention to smth.; neglect smth.:
- Robert let his teeth go when he was young and now he has to go to the dentist pretty often.