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Difference between Let go of something and Let go with something

let go of somethingstop holding smth.; release smth.:

  • As soon as I let go of the leash, the dog ran away.

let go with somethinggive vent to laughter, angry words, etc.:

  • The lawyer let go with a vicious attack on the tactics of his opponent.

Note: Neither expression correlates in meaning with the phrase let something gopay no attention to smth.; neglect smth.:

  • Robert let his teeth go when he was young and now he has to go to the dentist pretty often.