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Difference between Have a screw loose and There is a screw loose

have a screw loose—(coll.) be mentally defective or not acting normally:

  • I don’t go much with anarchists. It’s my judgment they nearly always have a screw loose.

there is a screw loose —(coll.) there is smth. wrong in the condition of things:

  • Now this may come into court, you know. If there is a screw loose anywhere, better mention it.

Note: Neither expression is antonymous in meaning to the phrase tighten up screws

1. suppress or “clamp down” on dissenters, etc.:

  • The president is using Russo-American rapprochement as a smokescreen for tightening up screws at home.

2. apply pressure; make smth. subject to more severe control:

  • Dellinger believed the victory was a result of his team tightening up screws on defense.