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Difference between Not in it and Not with it

not in it

1. not engaged in smth. as partners, competitors, etc.:

  • For the most part the faculty members were not in it [distance education programs] for the money.

2. (coll.) not worthy of comparison with the thing stated first:

  • Have you seen his new BMW? The old Opel isn’t in it!

not with it—(coll.)

1. not fully alert and aware of what is happening:

  • I forgot to stamp the letters I posted—I’m really not with it this morning.

2. not thinking or behaving in the most modern way:

  • That teacher will never be popular with the students, he’s just not with it.

See also: beyond it / off it / out of it.