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Difference between Set someone up and Upset someone

set someone up

1. (coll.) make a person feel better:

  • You need a holiday to set you up again after all that hard work.

2. help a person start as someone in business, etc.:

  • His father lent him some money to set him up as a shoemaker.

3. (often Passive) deliberately cause a person to receive blame, punishment, etc.:

  • I’m not to blame really; I’ve been set up.

Note: The expression is not antonymous in meaning to the phrase set someone downallow a person to leave a vehicle:

  • By the time a truck driver set me down among dark green hills, it was already time to start looking for a place to lay over.

upset someone—distress a person:

  • Deceased appeared very irritable upon the morning in question, but witness knew of nothing to upset him.